San Francisco 49ers vs. Jacksonville Jaguars Pick Prediction 11/21/2021 by Tony T.
49ers at Jaguars—San Francisco got on a positive track with a strong running game in their 31-20 home win to the Rams. Bad news for San Francisco as starting running back Elijah Mitchell is listed as doubtful with a finger injury. 49ers have been hit hard with injuries at this position. Jacksonville offense is trending poorly in their past three games with 286 yards with 172 yards passing for 4.4 yards per rush. They have converted only 28.6% on third down in this period and a poor 50% conversion rate in the red zone. Jaguars putting up only 11 points a game in this span. Play San Francisco and Jacksonville under 45.