Indianapolis Colts vs. Buffalo Bills Pick Prediction 11/21/2021 by Tony T.
Colts at Bills—Indianapolis has won four of five. Carson Wentz is healthy and is getting great help from his run game. Indianapolis run game past three games averaging 156 yards with 6.1 yards per rush. These teams met in the playoffs last year with he Bills winning by three as the Colts were able to run and move the ball through the air against the Bills. Buffalo have an offensive and defensive end out. Their middle linebacker questionable. Colts are a healthy team. Buffalo has one cover in their past four games. Play Indianapolis +7.5.