Indianapolis Colts vs. San Francisco 49ers Pick Prediction 10/24/2021 by Tony T.
Colts at 49ers—NFL free pick is Indianapolis Colts +4. Colts have covered three straight as their offense showing improvement under Carson Wentz and running back Jonathan Taylor. Wentz got one of his major weapons back in the passing game last week with the return of TY Hilton in their 31-3 win to Houston. In that three game period Wentz completing 70% of his passes for 9.8 yards per pass attempt. Run game has helped Wentz with 145 yards per game with 5.1 per rush. 49ers carry a three game losing streak as they return from their bye week with two losses coming at home. Rain is in the forecast at 86% chance with high winds. Jimmy Garoppolo expected back under center but completing only 61.9% of his passes at home for 6.7 yards per pass attempt. Team has suffered cluster injuries at running back. They will be without their two defensive tackle and offensiv