Ohio St vs. Indiana Pick Prediction 10/23/2021 by Tony T.
Ohio St at Indiana—College football pick is Ohio St Buckeyes -21. Ohio St has won four straight all by 21 or greater points. Past two Big Ten games the Buckeyes pounded Rutgers by 39 on the road and by 49 to Maryland at home. Against the Big Ten the Buckeyes are averaging 544 yards. Indiana struggling on the offensive end of the court. Starting quarterback Michael Penix is out with a shoulder injury. Backup Jack Tuttle completing 51.4% of his throws for 5.1 yards per pass attempt. In their three Big Ten games the Hoosiers averaging 7 points and 273 yards per game. Hoosiers have failed to cover all five against FBS competition. Play Ohio St -21.