1/5/25 San Francisco 49ers vs. Arizona Cardinals FREE NFL Week 18 Betting Pick


1/5/25 San Francisco 49ers vs. Arizona Cardinals FREE NFL Week 18 Betting Pick


San Francisco 49ers vs. Arizona Cardinals NFL Pick Prediction 1/5/2025 by Tony T.

49ers at Cardinals Injuries

San Francisco quarterback Purdy and receiver Samuel are out. Tight end Kittle and their right tackle are questionable. On defense a nickel back is out with safety questionable. Arizona receiver Wilson is questionable. On defense a linebacker and corner are questionable.

Recent Box Score Key Stats

49ers at Cardinals 4:25PM ET—San Francisco drops to 6-10 following their 40-34 home defeat to Detroit. The 49ers gained 475 yards with 75 rushing for 4.2 yards a carry. On defense they allowed 439 yards to the Lions with 152 rushing for 4.6 yards a carry. Prock Purdy hit 27 of 35 for 377 yards with three touchdowns and two interceptions. Arizona fell to 7-9 with their 13-9 road defeat at LA Rams. The Cardinals put up 296 yards with 113 rushing for 5.1 yards per run. Defensively they allowed 257 yards to the Rams with 68 rushing for 3.1 yards per run. Kyle Murray went 33 of 48 for 321 yards with a touchdown and two interceptions. They were playoff eliminated before the game.